It's a hormone produced by beta cells in the pancreas. It plays a crucial role in regulating blood sugar levels. Read More
Insulin is made in cells of the pancreas known as beta cells. Beta cells make up about 75% of pancreatic hormone cells.
In the beta cells, insulin is created first as a big molecule called “proinsulin.” Proinsulin is broken into two pieces: insulin and C-peptide. C-peptide is important especially when determining treatment because it can be used to measure how much insulin a person is making. The more C-peptide a person has, the more insulin they are making.
The beta cells of the pancreas can sense when blood sugar levels are rising or dropping, and release insulin into the bloodstream accordingly.
Insulin’s main function is to allow other cells to transform glucose into energy throughout your body. Without insulin, cells are starved for energy and must seek an alternate source. This can lead to life-threatening complications.
After a meal, the digestive tract breaks down carbohydrates and changes them into glucose. Glucose is then absorbed into your bloodstream through the lining in your small intestine. Once glucose is in your bloodstream, insulin causes cells throughout your body to absorb the sugar and use it for energy. Insulin also helps balance your blood glucose levels. When there’s too much glucose in your bloodstream, insulin signals your body to store the excess in your liver. The stored glucose isn’t released until your blood glucose levels decrease, such as between meals or when your body is stressed or needs an extra boost of energy.
The most common problem associated with insulin is diabetes. Diabetes occurs when the body either does not secrete enough insulin or when the body no longer uses the insulin it secretes effectively.
People who have prediabetes and Type 2 diabetes usually have some level of insulin resistance.
Diabetes falls into three categories:
Type 1 diabetes (T1D) occurs when the pancreas cannot produce insulin sufficiently to meet its own needs.
The body does not make its own insulin because the insulin-producing cells of the pancreas have been damaged or destroyed. People w/ T1D must administer insulin so that the body can process glucose.
Type 2 diabetes (T2D) is more commonly associated with adults and lifestyle choices. People with type 2 diabetes will produce insulin but often not enough for their body’s needs.
The body does not respond or is resistant to the insulin produced by the pancreas. People with T2D may need to administer insulin to help them better process glucose.
Insulin levels are typically requested when there is a low blood glucose test result or when someone presents with acute or chronic symptoms of hypoglycemia, which can be caused by conditions such as insulinoma. Symptoms of hypoglycemia include sweating, palpitations, hunger, confusion, blurred vision, dizziness, and fainting. These tests help doctors to assess the insulin production and function in the body to determine the underlying cause of low blood glucose levels and guide appropriate treatment.
The most common cause of low insulin is type 1 diabetes, an autoimmune disease in which the pancreatic cells that normally produce insulin are destroyed ,Pancreatic Disease or Removal Diseases that impair pancreatic function or damage the pancreas, other than type 1 diabetes, also lower insulin levels. One example is inflammation in the pancreas or pancreatitis Insulin levels will also drop after pancreatectomy, a surgery to remove all or part of the pancreas. This procedure may be performed to transplant part of a donor’s healthy pancreas into a diabetic patient .Hypopituitarism or pituitary insufficiency is a rare condition in which the pituitary gland doesn’t make enough hormones. People with this condition have lower insulin levels
Excessive thirst, frequent urination, excessive hunger, fatigue, blurred vision, and slow-healing sores are common symptoms associated with various underlying health issues. These symptoms may indicate conditions such as diabetes, where elevated blood sugar levels lead to increased thirst and urination, along with fatigue and hunger due to the body's inability to use glucose effectively. Blurred vision can result from changes in fluid levels in the eye due to fluctuating blood sugar. Slow-healing sores are often a consequence of impaired immune function or circulation, which can occur in diabetic individuals or those with other chronic conditions affecting blood sugar regulation.
sugar cravings unintentional weight gain excessive hunger issues with concentration anxiety or feelings of panic extreme tiredness
Fasting Insulin Test: Measures insulin levels in the blood after an overnight fast. This test helps diagnose insulin resistance and monitor insulin levels in people with diabetes or related conditions. C-peptide Test: Measures the level of C-peptide, a protein that is produced at the same time as insulin. This test helps determine how much insulin the body is producing on its own, distinguishing between insulin produced by the body and insulin taken as medication. HOMA-IR (Homeostasis Model Assessment of Insulin Resistance): This is a calculation based on fasting glucose and insulin levels, used to estimate insulin resistance. It is often used in research and clinical settings to assess insulin sensitivity. Insulin Antibody Test: Measures antibodies against insulin, which can be helpful in diagnosing autoimmune conditions affecting insulin production.
It will take few hours to get the result